Problem
Today when I tried to remove some user profiles on my server, I got an error message “Cannot delete NTUSER.dat: It is being used by another person or program”. I’ve checked if there is an application open this file, but I found nothing. I tried remove this file using an application called “ForceDelete.exe” but still could not delete this file.
Solution
You can download tool called “User Profile Hive Cleanup Service” from microsoft. I’ve tried to download and installed this tool in my server. After installation is finish, navigate to C:\program files\UPHClean using windows explorer. Run the exe file than try to remove the profile again. It’s working for me 
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